产品货号：
JN1919
中文名称：
重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)
英文名称：
Recombinant Human E3 Ubiquitin-Protein Ligase CHIP
产品规格：
10μg|50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Tyr303表达纯化得来。
STUB1/CHIP质量控制：＞95%(还原性SDS-PAGE)
STUB1/CHIP制剂：液体
STUB1/CHIP保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于STUB1/CHIP：
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
相关搜索：重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)
STUB1/CHIP质量控制：＞95%(还原性SDS-PAGE)
STUB1/CHIP制剂：液体
STUB1/CHIP保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于STUB1/CHIP：
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
相关搜索：重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)